IAS 2025 IAS 2025

International Astrocyte School

International Astrocyte School

Bertinoro, Italy • 6-13 April 2025

Bertinoro, Italy • 6-13 April 2025

Programme

Programme

  • Sun
    6 April
  • Mon
    7 April
  • Tue
    8 April
  • Wed
    9 April
  • Thu
    10 April
  • Fri
    11 April
  • Sat
    12 April
  • Sun
    13 April
  • Sunday, 6 April

    All afternoon

    Arrivals and room check-in

    18:00-18:30

    Registration

    18:30

    Welcome ceremony
    Introduction to the school, general information, and assignment of students to Agora groups

    19:30

    Welcome drinks followed by buffet dinner

  • Monday, 7 April

    9:00-9:45

    Richard Robitaille (Université de Montréal • Montréal, Canada)
    Ca2+ imaging tools: modes of action and limitations
    [30 min + 10 min discussion]

    9:45-10:30

    Amit Agarwal (Heidelberg University • Heidelberg, Germany)
    Astrocyte Ca2+ signals: analysis and interpretation
    [30 min + 10 min discussion]

    10:30-10:50

    Coffee break

    10:50-11:35

    Alfonso Araque (University of Minnesota • Minneapolis, MN, USA)
    Stimulating neurons and astrocytes
    [30 min + 10 min discussion]

    11:35-12:40

    Student presentations 1

    [7 min + 3 min discussion each]

    Simon Alvado (Montréal, Canada)
    Efficacy and quality of neuromuscular junction reinnervation: impacts in ALS

    Rafael Falcon Moya (Minneapolis, MN, USA)
    Enhancement of synaptic plasticity and learning mediated by dopaminergic activation of hippocampal astrocytes

    Nikola Habek (Zagreb, Croatia)
    GABA transporter 3 in the interaction between astrocytes and hippocampal interneurons

    Jacob Noeker (Minneapolis, MN, USA)
    Serotonin-induced astrocyte activity: neuromodulatory control of fear behavior

    Alicia Rey (Lausanne, Switzerland)
    The role of astrocytic fatty acid beta-oxidation in the postnatal and adult mouse brain

    Rafaela Seixas (Oporto, Portugal)
    Investigating astrocytic heterogeneity at the level of individual perisynaptic processes

    12:40-12:55

    Agora • Info & Preparation (1)

    13:00-14:30

    Lunch

    14:35-15:40

    Student presentations 2

    [7 min + 3 min discussion each]

    Fabio Allia (Enna, Italy)
    Glial cells in rare neurodegenerative disorders: a focus on Krabbe disease

    Isabel Anaí Echeverría Oviedo (Leuven, Belgium)
    The role of astrocyte-neuron interactions in the brain’s recovery from sensory loss

    Arthur Aleksandrovich Ermakov (Utrecht, The Netherlands)
    Exploring reactive gliosis in dementia with human iPSC-derived models: gaining mechanistic insight and assessing functional impact

    Marieke Krepel (Amsterdam, The Netherlands)
    Proteostatic neuron to astrocyte signalling induced by tau pathology

    Anita Lygeroudi (Amsterdam, The Netherlands)
    Ceramide levels elucidated in astrocyte reactivity in Alzheimer’s disease

    Mariacristina Mazzitelli (Lubbock, TX, USA)
    The role of amygdala astrocytes in the development of chronic pain

    15:40-16:25

    Frank Kirchhoff (University of Saarland • Homburg, Germany)
    Genetic mouse models to study astrocyte physiology in vivo
    [30 min + 10 min discussion]

    16:25-16:45

    Coffee break

    16:45-18:00

    Student presentations 3

    [7 min + 3 min discussion each]

    Matilde Amat di San Filippo (Bern, Switzerland)
    Diversity of astrocyte signalling in neuronal plasticity and memory formation

    Sofia Barile (Genoa, Italy)
    Deciphering astrocytic involvement in valence processing within the dorsal raphe nucleus (DRN)

    Clara Franco (Paris, France)
    A flexible hypothalamic astrocyte network adapts to high-energy diet in a sex-dependent manner

    Shay Meron Asher (Jerusalem, Israel)
    How do astrocytic activity and astrocytic domains affect hippocampal neuronal place cells?

    Ingrid Peterson (Tucson, AZ, USA)
    Understanding the role of brainstem glial dysfunction during medication overuse headache

    Lisa Porschen (Lund, Sweden)
    High-fat diet-induced alterations of cerebrovascular S1P signaling in experimental stroke

    Saana Seppälä (Tampere, Finland)
    Biophysically and morphologically detailed computational models for neuron-astrocyte interactions in health and disease

    20:00

    Dinner

  • Tuesday, 8 April

    09:00-9:55

    Student presentations 4

    [7 min + 3 min discussion each]

    Naama Brezner (Montréal, Canada)
    DNA methylation in astrocyte maturation

    Max Gentenaar (Leiden, The Netherlands)
    Single-nucleus sequencing in R6/2 mice reveals Huntington’s disease specific cell populations and partial transcriptional normalization by GR antagonism

    Ombeline Gruere (Homburg, Germany)
    Molecular characterization and functional Integration of Fañanas Cells in the mouse cerebellum

    Agathe Lafont (Montréal, Canada)
    Exploring vulnerability across NMJs in ALS: physiological and transcriptomic insights

    Bohan Li (Beijing, China)
    Multiplex imaging of purinergic dynamics in vivo with an expanded toolbox of GRAB sensors

    9:55-10:40

    Matthew Holt (University of Porto • Oporto, Portugal)
    The expanding RNA-seq toolkit and its application to astrocyte biology
    [30 min + 10 min discussion]

    10:40-11:00

    Coffee break

    11:00-11:55

    Student presentations 5

    [7 min + 3 min discussion each]

    Alessia Memeo (Bari, Italy)
    S-palmitoylation dependence of AQP4-M1 tetramers dynamics

    Marta Mestroni (Bordeaux, France)
    Cannabinergic astrocytes may mediate eCB activity through linoleic acid metabolism in mice

    George Sideris-Lampretsas (London, United Kingdom)
    Serotonin-mediated pericyte constriction in health and Alzheimer’s disease

    Ghanendra Singh (Graz, Austria)
    Modeling astrocytic blood brain barrier and sex-specific contribution in major depressive disorder

    Sara Sposito (Rome, Italy)
    Inducible pluripotent stem (iPS) cell-derived human astrocytes as a new disease model for the megalencephalic leukoencephalopathy with subcortical cysts (MLC): searching for shared pathological mechanisms of myelin degeneration in astrocytopathies

    11:55-12:40

    Keith Murai (McGill University Health Centre • Montréal, Canada)
    Targeting astrocytes: labeling approaches for astrocyte visualization and molecular manipulation
    [30 min + 10 min discussion]

    12:45-14:15

    Lunch

    14:20-15:15

    Student presentations 6

    [7 min + 3 min discussion each]

    Natalia Quiroz Correa (Medellin, Colombia)
    Astrocyte-like cells derived from menstrual blood-derived mesenchymal stromal cells: an efficient platform for disease modeling and therapy testing

    Lucille Torres (Saclay, France)
    Analysis of mouse subicular astrocytes in the context of Alzheimer’s disease

    Anna Törteli (Szeged, Hungary)
    Spreading depolarization causes reperfusion failure after acute ischemic stroke

    Lola Ugalde-Triviño (Madrid, Spain)
    Interactions established by isoform-specific TrkB-T1 sequences govern inflammatory response and neurotoxicity in stroke

    Diego Julian Vesga Jimenez (Regensburg, Germany)
    Astrocytes phagocytic sexual dimorphism fosters Major Depressive Disorder through MEGF10 dysfunction

    15:15-16:00

    Rosa C. Paolicelli (University of Lausanne • Lausanne, Switzerland)
    The relevance of functional assays to understand microglial complexity
    [30 min + 10 min discussion]

    16:00-18:00

    Agora • Preparation (2) [with coffee]
    Students divided in groups

    20:00

    Pizza party

  • Wednesday, 9 April

    9:00-9:45

    Giovanni Marsicano (INSERM • Bordeaux, France)
    Behavioural studies: data first, interpretations later
    [30 min + 10 min discussion]

    9:45-10:30

    Elly Hol (UMC Utrecht • Utrecht, The Netherlands)
    Human astrocytes: from postmortem brains to iPSC models
    [30 min + 10 min discussion]

    10:30-10:50

    Coffee break

    10:50-11:35

    Kerstin Lenk (Graz University of Technology • Graz, Austria)
    Computational astrocyte models at the single-cell level
    [30 min + 10 min discussion]

    11:35-12:20

    Mark Verheijen (Vrije Universiteit • Amsterdam, The Netherlands)
    Molecular analysis of astrocyte subdomains
    [30 min + 10 min discussion]

    12:25-13:30

    Lunch

    13:45

    Departure to Ravenna
    Sightseeing and guided tours, followed by dinner
    Return to Bertinoro after dinner

  • Thursday, 10 April

    9:00-9:45

    Amit Agarwal (Heidelberg University • Heidelberg, Germany)
    Decoding mitochondrial dynamics in cortical astrocytes
    [30 min + 10 min discussion]

    9:45-10:30

    Shan Bian (Tongji University • Shanghai, China)
    Using brain organoids to understand the evolution and development of human brains
    [30 min + 10 min discussion]

    10:30-10:50

    Coffee break

    10:50-11:35

    Alfonso Araque (University of Minnesota • Minneapolis, MN, USA)
    Scaling up tripartite synapses: from synapses to network and behavior
    [30 min + 10 min discussion]

    11:35-12:20

    Keith Murai (McGill University Health Centre • Montréal, Canada)
    Structural signatures of astrocytes in CNS health and disease
    [30 min + 10 min discussion]

    12:25-13:55

    Lunch

    14:00-14:45

    Frank Kirchhoff (University of Saarland • Homburg, Germany)
    The astroglial GABAB receptor and absence epilepsy – sex-specific differences in response to GHB
    [30 min + 10 min discussion]

    14:45-15:30

    Kerstin Lenk (Graz University of Technology • Graz, Austria)
    Computational astrocyte models at the network level
    [30 min + 10 min discussion]

    15:30-18:00

    Agora • Preparation (3) [with coffee]
    Students divided in groups

    20:00

    Dinner

  • Friday, 11 April

    9:00-9:45

    Rosa C. Paolicelli (University of Lausanne • Lausanne, Switzerland)
    Early microglia dysfunction in brain diseases
    [30 min + 10 min discussion]

    9:45-10:30

    Elly Hol (UMC Utrecht • Utrecht, The Netherlands)
    The astrocyte cytoskeleton in brain diseases
    [30 min + 10 min discussion]

    10:30-10:50

    Coffee break

    10:50-11:35

    Giovanni Marsicano (INSERM • Bordeaux, France)
    CB1 receptor in astrocytes: a link between metabolism and synapses
    [30 min + 10 min discussion]

    11:35-12:20

    Matthew Holt (University of Porto • Oporto, Portugal)
    Astrocytes: central players in differential synaptogenesis?
    [30 min + 10 min discussion]

    12:25-13:55

    Lunch

    14:00-14:45

    Mark Verheijen (Vrije Universiteit • Amsterdam, The Netherlands)
    Astrocyte-synapse contacts in memory function
    [30 min + 10 min discussion]

    14:45-15:30

    Giorgio Carmignoto (CNR Institute of Neurosciences • Padua, Italy)
    A novel view of astrocyte Ca2+ dynamics in brain functioning
    [30 min + 10 min discussion]

    15:30-16:15

    Richard Robitaille (Université de Montréal • Montréal, Canada)
    Glial cells regulate neuromuscular junction in health and disease
    [30 min + 10 min discussion]

    16:15-18:00

    Agora Preparation (4) [with coffee]
    Students divided in groups

    20:00

    Dinner

  • Saturday, 12 April

    9:00-11:30

    Agora presentations [with coffee]
    All students. One group after another; order to be defined at the moment
    [3 x 45-min presentations]

    11:30-12:00

    General discussion, Concluding Remarks, Questionnaires

    12:00-13:30

    Lunch

    13:30

    Social activities
    (to be defined)

    20:00

    Farewell Dinner

  • Sunday, 13 April

    Departure